Skip to content
Pregnancy

The First 1,000 Days of Life: The Foundations of Future Health

The first 1,000 days of life, from conception to early childhood, shape a child’s future health. Nutrition, lifestyle, environment, and parents’ well-being influence development through epigenetics and the microbiome, and healthy choices help build immunity and prevent disease.

Ritratto di una fondatrice Mairuna seduta su un divano con luce calda sullo sfondo
Giorgia NadinThu, April 30, 2026
natura_1000 giorni_crescita_mairuna

The foundations of future health

A child's health doesn't begin at birth. It begins much earlier: during pregnancy, and even in the preconception period.

The first 1,000 days of life, from conception to around age two or three, are a crucial phase for a child’s development and future health.

During this period, factors like nutrition, lifestyle, stress, and environment have a profound effect on growth and well-being.


Epigenetics and the first 1,000 days: why they matter so much

Scientific research, especially in the field of epigenetics, shows that external factors can influence how genes are expressed without changing the DNA itself.

In other words, the parents’ lifestyle can “switch on or switch off” certain genes in the child.

Among the most important factors:

  • the mother’s and father’s diet
  • stress
  • environmental pollution
  • maternal health conditions
  • the quality of the microbiome

These factors affect the risk of developing chronic diseases, metabolic disorders, and immune problems over the course of a lifetime.


The microbiome: a key ally for health

The human microbiome is the community of microorganisms that live in our body (bacteria, viruses, fungi), and it plays an essential role in our health.

The gut microbiome, in particular, is the most important one and is often called the “second brain.”

Every microbiome is unique and develops based on several factors:

  • type of birth
  • feeding (breast milk or formula)
  • antibiotic use
  • lifestyle
  • sleep and physical activity

A balanced microbiome:

  • supports the immune system
  • protects against pathogens
  • regulates inflammation
  • contributes to mental well-being

An imbalance (dysbiosis), on the other hand, can contribute to gut disorders, chronic diseases, and immune changes.


How to support health in the first 1,000 days

There are several stages where you can take concrete steps to build the foundations of your child’s health.

Preconception

The parents’ health is the first step:

  • a healthy, high-quality diet
  • regular physical activity
  • quitting smoking and cutting out alcohol
  • good-quality sleep

Folic acid in pregnancy

Taking folic acid (400 mcg a day) is recommended from the time you start trying to conceive and at least through the first trimester.

Mindful use of medications

Medications should be used only when necessary and under medical supervision.
Antibiotics, in particular, can disrupt the microbiome of both mother and newborn.

Maternal microbiome health

The mother’s gut, oral, and vaginal microbiome directly influences the baby’s, starting in the womb.

Reducing pollutants

It’s important to limit exposure to substances like BPA and PFAS (endocrine disruptors) by choosing carefully:

  • food (know where it comes from, and favor seasonal and organic options)
  • containers (choose glass or ceramic)
  • cleaning products (avoid harsh detergents that leave residue on dishes)

Type of birth

Vaginal birth promotes greater microbiome diversity (lactobacilli and bifidobacteria), while a cesarean (C-section) can result in less diversity (staphylococci, or bacteria from the environment or from health care staff, are often found)

Skin-to-skin contact

Immediate contact between mother and newborn:

  • helps regulate temperature
  • stabilizes blood sugar
  • makes breastfeeding easier
  • enriches the microbiome

Feeding your newborn

Breastfeeding promotes the growth of beneficial bacteria.
Formula may lead to lower microbial diversity.

This article takes a closer look at the topic: Breast milk or formula: are they really equivalent?

Relationships and the family environment

Emotional factors matter too:


Conclusion

The first 1,000 days of life are a unique window for building the foundations of long-term health.

Through informed choices, you can have a positive influence on your child’s microbiome, immune system, and epigenetic mechanisms.

Investing in this stage means taking care of the future.


The First 1,000 Days of Life: The Foundations of Future Health